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Brain wave patterns have shown distinct changes during orgasm, which indicate the importance of the limbic system in the orgasmic response.[2] Male and female brains demonstrate similar changes during orgasm, with brain activity scans showing a temporary decrease in the metabolic activity of large parts of the cerebral cortex with normal or increased metabolic activity in the limbic areas of the brain.[4]

In humans, orgasms usually result from the stimulation of the penis in males, usually accompanying ejaculation, and the clitoris in females.[2][5] Stimulation can be by self-practice (masturbation) or by a partner (penetrative sexual intercourse, non-penetrative sex, and other erotic sexual activities). In addition, partners simultaneously stimulating each other's sex organs by mutual masturbation, penetrative intercourse, or other rhythmic inter-genital contact may experience simultaneous orgasms.

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